CBD Does Not Get You High
The first thing to know about CBD is that it is not psychoactive; it doesn’t get people high. The primary psychoactive ingredient in marijuana is tetrahydrocannabinol (THC). But THC is only one of the scores of chemicals – known as cannabinoids – produced by the cannabis plant. So far, CBD is the most promising compound from both a marketing and a medical perspective. Many users believe it helps them relax, despite it not being psychoactive, and some believe regular doses help stave off Alzheimer’s and heart disease.
You Don’t Need a Prescription to Get CBD Oil
However, the US Food and Drug Administration approved Epidiolex, a pharmaceuticalized form of CBD for several severe pediatric seizure disorders. According to data recently published in the New England Journal of Medicine, the drug can reduce seizures by more than 40%. If Epidiolex wins approval it would be the first time the agency approves a drug derived from the marijuana plant. (The FDA has approved synthetic THC to treat chemotherapy-related nausea.) Epidiolex was developed by the London-based GW Pharmaceuticals, which grows cannabis on tightly controlled farms in the UK. It embarked on the Epidiolex project in 2013, as anecdotes of CBD’s value as an epilepsy drug began emerging from the US.
It Reduces Seizures In Children
CBD first came to public attention in a 2013 CNN documentary called Weed. The piece, reported by Dr Sanjay Gupta, featured a little girl in Colorado named Charlotte, who had a rare life-threatening form of epilepsy called Dravet syndrome. At age five, Charlotte suffered 300 grand mal seizures a week, and was constantly on the brink of a medical emergency. Through online research, Charlotte’s desperate parents heard of treating Dravet with CBD. It was controversial to pursue medical marijuana for such a young patient, but when they gave Charlotte oil extracted from high-CBD cannabis, her seizures stopped almost completely. In honor of her progress, high-CBD cannabis is sometimes known as Charlotte’s Web.
CBD Is Great For Many Illnesses
Cannabidiol is one of 85+ cannabinoids found in the cannabis plant, and much of the ongoing research has found it to be a promising potential therapy for many illnesses that medical professionals have previously thought to be untreatable, including: Pain (neuropathic, chronic, cancer-related, etc.) Epilepsy Multiple Sclerosis (MS) Amyotrophic Lateral Sclerosis (ALS) Parkinson’s Inflammation Acne Dyskinesia Psoriasis Broken Bones Mad Cow Disease Depression Bacterial Infections Diabetes Rheumatoid Arthritis Nausea Anxiety ADHD Schizophrenia Substance Abuse/Withdrawal Heart Disease Irritable Bowel Syndrome
There’s No Physical Reaction To Ingesting Too Much CBD
If you accidentally indulge in a few too many spoonfuls of CBD oil, Sayegh says not to sweat it. “There’s no physical reaction to it,” he explains—as long as whatever product you’re ingesting doesn’t contain THC. (In fact, clinical trials have shown you’d need to ingest a dose equivalent to 20 mg per each kilogram of your body weight—AKA a ton—to experience negative physical side effects.)
You Can Think Of Your Daily Dose Of CBD Like A Vitamin
You can take your daily CBD dose in tandem with the rest of your supplemental routine of vitamin D, omegas, and probiotics (or whatever your healthy cocktail of choice). It is recommended to take 5 mg of CBD to kickstart your morning. If you want to use CBD as a sleep aid, 15 mg should do the trick, and when using the ingredient to help soothe muscle aches and pains, 5-35 mg is recommended. In extreme cases like Autism, Epilepsy, Chronic Pain, Seizures, 33-66mg is recommended. (Extra Strength)
Pure CBD vs Pharmaceutical CBD?
Concerning the pharmaceutical product that the FDA approved to treat two types of epilepsy, researchers noticed following adverse effects in clinical trials: liver problems symptoms related to the central nervous system, such as irritability and lethargy reduced appetite gastrointestinal problems infections rashes and other sensitivity reactions reduced urination breathing problems The patient information leaflet notes that there is a risk of worsening depression or suicidal thoughts. It is important to monitor anyone who is using this drug for signs of mood change.
CBD Effects Several Neurotransmitter Receptors
At high doses, CBD activates the 5-ht1A receptor. The 5-ht1A receptor helps regulate anxiety, addiction, appetite, sleep, pain perception, nausea, and vomiting. CBDA (the raw form of CBD) shows an even higher affinity for the 5-ht1A receptor than CBD. CBD also antagonizes GPR55 receptors. GPR55 receptors are widely distributed in the brain (especially the cerebellum) and help to control bone density and blood pressure. When activated, GPR55 promotes cancer cell proliferation. This antagonizing action may help explain the natural value of supplementing with CBD in individuals with cancer, osteoporosis, and high blood pressure. CBD activates TRPV1 receptors. TRPV1 is involved in regulating pain, body temperature, and inflammation. Other substances targeting TRPV1 receptors include anandamide, AM404 (a metabolite of acetaminophen), capsaicin, and various cannabinoids such as CBN, CBG, CBC, THCV, and CBDV. Lastly, CBD activates PPAR-gamma receptors. PPAR-gamma receptors are located on the cell’s nuclei and play a role in lipid uptake, insulin sensitivity, dopamine release and the degradation of beta-amyloid plaque. This is why CBD has been found to have natural value for individuals with diabetes, schizophrenia, and Alzheimer’s disease.